Recent publications
Murine Respiratory Tract Infection with Classical Klebsiella pneumoniae Induces Bronchus-Associated Lymphoid Tissue
March 21, 2022
Wasbotten RK, Dahler AA, Mackel JJ, Morffy Smith C, Rosen DA. Murine Respiratory Tract Infection with Classical Klebsiella pneumoniae Induces Bronchus-Associated Lymphoid Tissue. Infect Immun. 2022 Mar 21:e0059621. doi: 10.1128/iai.00596-21. Epub ahead of print. PMID: 35311545.
A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection
March 26, 2020
Twentyman J, Morffy Smith C, Nims JS, Dahler AA, Rosen DA. A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection. Dis Model Mech. 2020 Mar 26;13(3):dmm043240. doi: 10.1242/dmm.043240. PMID: 32298236; PMCID: PMC7104859.
A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae
September 10, 2019
Feldman MF, Mayer Bridwell AE, Scott NE, Vinogradov E, McKee SR, Chavez SM, Twentyman J, Stallings CL, Rosen DA, Harding CM. A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18655-18663. doi: 10.1073/pnas.1907833116. Epub 2019 Aug 27. PMID: 31455739; PMCID: PMC6744904.
Whole-Genome Sequencing of Klebsiella pneumoniae Isolates to Track Strain Progression in a Single Patient With Recurrent Urinary Tract Infection
February 8, 2019
Wylie KM, Wylie TN, Minx PJ, Rosen DA. Whole-Genome Sequencing of Klebsiella pneumoniae Isolates to Track Strain Progression in a Single Patient With Recurrent Urinary Tract Infection. Front Cell Infect Microbiol. 2019 Feb 8;9:14. doi: 10.3389/fcimb.2019.00014. PMID: 30800643; PMCID: PMC6375827.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola
December 18, 2018
Potter RF, Lainhart W, Twentyman J, Wallace MA, Wang B, Burnham CA, Rosen DA, Dantas G. Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola. mBio. 2018 Dec 18;9(6):e02481-18. doi: 10.1128/mBio.02481-18. PMID: 30563902; PMCID: PMC6299229.
In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase
October 15, 2018
Svetlov D, Shi D, Twentyman J, Nedialkov Y, Rosen DA, Abagyan R, Artsimovitch I. In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase. Mol Microbiol. 2018 Oct;110(1):128-142. doi: 10.1111/mmi.14093. Epub 2018 Oct 2. PMID: 30069925; PMCID: PMC6595482.
High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung
January 22, 2018
Rosen DA, Twentyman J, Hunstad DA. High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun. 2018 Jan 22;86(2):e00647-17. doi: 10.1128/IAI.00647-17. PMID: 29158434; PMCID: PMC5778367.
Klebsiella pneumoniae FimK promotes virulence in murine pneumonia
February 15, 2016
Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016 Feb 15;213(4):649-58. doi: 10.1093/infdis/jiv440. Epub 2015 Sep 7. PMID: 26347570; PMCID: PMC4721909.