Featured publications
A heptavalent O-antigen bioconjugate vaccine exhibits differential functional antibody responses against diverse Klebsiella pneumoniae isolates
February 24, 2024
Wantuch PL, Knoot CJ, Robinson LS, Vinogradov E, Scott NE, Harding CM, Rosen DA. A heptavalent O-antigen bioconjugate vaccine exhibits differential functional antibody responses against diverse Klebsiella pneumoniae isolates. J Infect Dis. 2024 Feb 24:jiae097. doi: 10.1093/infdis/jiae097. Epub ahead of print. PMID: 38401891.
Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae
May 5, 2023
Wantuch PL, Knoot CJ, Robinson LS, Vinogradov E, Scott NE, Harding CM, Rosen DA. Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae. PLoS Pathog. 2023 May 5;19(5):e1011367. doi: 10.1371/journal.ppat.1011367. PMID: 37146068; PMCID: PMC10191323.
A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection
March 26, 2020
Twentyman J, Morffy Smith C, Nims JS, Dahler AA, Rosen DA. A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection. Dis Model Mech. 2020 Mar 26;13(3):dmm043240. doi: 10.1242/dmm.043240. PMID: 32298236; PMCID: PMC7104859.
A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae
September 10, 2019
Feldman MF, Mayer Bridwell AE, Scott NE, Vinogradov E, McKee SR, Chavez SM, Twentyman J, Stallings CL, Rosen DA, Harding CM. A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18655-18663. doi: 10.1073/pnas.1907833116. Epub 2019 Aug 27. PMID: 31455739; PMCID: PMC6744904.
Whole-Genome Sequencing of Klebsiella pneumoniae Isolates to Track Strain Progression in a Single Patient With Recurrent Urinary Tract Infection
February 8, 2019
Wylie KM, Wylie TN, Minx PJ, Rosen DA. Whole-Genome Sequencing of Klebsiella pneumoniae Isolates to Track Strain Progression in a Single Patient With Recurrent Urinary Tract Infection. Front Cell Infect Microbiol. 2019 Feb 8;9:14. doi: 10.3389/fcimb.2019.00014. PMID: 30800643; PMCID: PMC6375827.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola
December 18, 2018
Potter RF, Lainhart W, Twentyman J, Wallace MA, Wang B, Burnham CA, Rosen DA, Dantas G. Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola. mBio. 2018 Dec 18;9(6):e02481-18. doi: 10.1128/mBio.02481-18. PMID: 30563902; PMCID: PMC6299229.
In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase
October 15, 2018
Svetlov D, Shi D, Twentyman J, Nedialkov Y, Rosen DA, Abagyan R, Artsimovitch I. In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase. Mol Microbiol. 2018 Oct;110(1):128-142. doi: 10.1111/mmi.14093. Epub 2018 Oct 2. PMID: 30069925; PMCID: PMC6595482.
High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung
January 22, 2018
Rosen DA, Twentyman J, Hunstad DA. High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun. 2018 Jan 22;86(2):e00647-17. doi: 10.1128/IAI.00647-17. PMID: 29158434; PMCID: PMC5778367.
Recent publications
- Vaccine value profile for Klebsiella pneumoniaeDangor, Z., Benson, N., Berkley, J. A., Bielicki, J., Bijsma, M. W., Broad, J., Buurman, E. T., Cross, A., Duffy, E. M., Holt, K. E., Iroh Tam, P. Y., Jit, M., Karampatsas, K., Katwere, M., Kwatra, G., Laxminarayan, R., Le Doare, K., Mboizi, R., Micoli, F. & Moore, C. E. & 12 others, Nakabembe, E., Naylor, N. R., O'Brien, S., Olwagen, C., Reddy, D., Rodrigues, C., Rosen, D. A., Sadarangani, M., Srikantiah, P., Tennant, S. M., Hasso-Agopsowicz, M. & Madhi, S. A., Jul 25 2024, In: Vaccine. 42, 19, p. S125-S141Research output: Contribution to journal […]
- Lung infection with classical Klebsiella pneumoniae strains establishes robust macrophage-dependent protection against heterologous reinfectionMackel, J. J., Mick, C. L. G., Guo, E. & Rosen, D. A., 2024, (Accepted/In press) In: Microbes and Infection. 105369.Research output: Contribution to journal › Article › peer-review
- Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizonsWantuch, P. L. & Rosen, D. A., Oct 2023, In: Trends in Immunology. 44, 10, p. 826-844 19 p.Research output: Contribution to journal › Review article › peer-review
- Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pHDistel, J. S., Di Venanzio, G., Mackel, J. J., Rosen, D. A. & Feldman, M. F., Jun 2023, In: PLoS pathogens. 19, 6, e1011173.Research output: Contribution to journal › Article › peer-review
- Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniaeWantuch, P. L., Knoot, C. J., Robinson, L. S., Vinogradov, E., Scott, N. E., Harding, C. M. & Rosen, D. A., May 2023, In: PLoS pathogens. 19, 5, e1011367.Research output: Contribution to journal › Article › peer-review
- Listserv to Support Community Pediatric Clinicians During the COVID-19 PandemicSmith, G. D., Thomas, S. L., Orscheln, R. C., Reyes, S. M., Reyes, S. A., Rosen, D. A., Terrill, C. M., Dodd, S., Plax, K. & Newland, J. G., Apr 1 2023, In: Journal of the Pediatric Infectious Diseases Society. 12, 4, p. 254-255 2 p.Research output: Contribution to journal › Letter › peer-review
- Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae familyKnoot, C. J., Wantuch, P. L., Robinson, L. S., Rosen, D. A., Scott, N. E. & Harding, C. M., Jan 8 2023, In: Glycobiology. 33, 1, p. 57-74 18 p.Research output: Contribution to journal › Article › peer-review
- Airway multidrug-resistant organisms in a population of tracheostomy and chronic ventilator-dependent children at a tertiary care pediatric hospitalHavens, T. N., Rosen, D. A. & Rivera-Spoljaric, K., Jan 2023, In: Pediatric Pulmonology. 58, 1, p. 26-34 9 p.Research output: Contribution to journal › Article › peer-review
- Skin Findings of Impetigo Neonatorum and Staphylococcal Scalded Skin SyndromeDaniels, E. A. & Rosen, D. A., Dec 2022, In: Journal of Pediatrics. 251, p. 216-217 2 p.Research output: Contribution to journal › Article › peer-review
- Classical and γδ T cells are each independently sufficient to establish protection against a classical strain of Klebsiella pneumoniaeMackel, J. J., Morffy Smith, C., Wasbotten, R. K., Twentyman, J. & Rosen, D. A., Aug 31 2022, In: Frontiers in cellular and infection microbiology. 12, 974175.Research output: Contribution to journal › Article › peer-review